Cancer chemotherapy: DNA amplification and multidrug resistance
نویسندگان
چکیده
منابع مشابه
Cancer multidrug resistance (MDR): a major impediment to effective chemotherapy.
Multidrug resistance (MDR) continues to be a major challenge to effective chemotherapeutic interventions against cancer. Various types of cancers have been observed to exhibit this phenomenon, a strategy that involves cellular and non cellular mechanisms employed by cancer cells to survive the cytotoxic actions of various structurally and functionally unrelated drugs. The present article is a b...
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Soon after the introduction of daunomycin and cytosine arabinoside (i.e., cytarabine) in the early 1960’s, several reports appeared examining the effects of these agents on bone marrow and peripheral blood cells (1,2). A surprisingly high percentage of normal cells, as many as 92% in some patients treated with daunomycin, had gross chromosomal damage. As we look back on these early studies, it ...
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ژورنال
عنوان ژورنال: Nature
سال: 1984
ISSN: 0028-0836,1476-4687
DOI: 10.1038/309580a0